Our Research Team

We are a diverse group of scientists studying cell surface receptors and their downstream signaling networks.

 
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Lemmon Lab — Members

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Mark Lemmon, Ph.D., F.R.S.

Mark Lemmon, PhD was appointed the Co-Director of the Cancer Biology Institute and the David A. Sackler Professor of Pharmacology in 2015. Dr. Lemmon returns to Yale, where he completed his PhD in 1993, from the University of Pennsylvania’s Perelman School of Medicine. At UPenn, he was the George W. Raiziss Professor of Biochemistry and Biophysics as well as Chair of the department and an Investigator at the Abramson Family Cancer Research Institute. Dr. Lemmon’s research focuses on the signaling pathways of receptor tyrosine kinases (RTKs), which, when mutated cause cancers and other diseases. Email Mark at mark.lemmon[at]yale.edu.


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Kumar Ashtekar, Ph.D.

Kumar is a synthetic chemist by training and works on development of kinase inhibitors with novel reversible and irreversible covalent warheads using computational, physical and organic chemistry tools. Email Kumar at kumar.ashtekar[at]yale.edu.

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Chun Hu

Chun is a graduate student in pharmacology studying different mechanisms of EGF receptor signaling by its various ligands, and understand the molecular basis of oncogenic EGFR ectodomain variants found in glioblastoma.  Outside of lab, Chun enjoys kickboxing, homecooking, and watching french bulldog videos! Email Chun at chun.hu[at]yale.edu.

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Anatoly Kiyatkin, Ph.D.

Anatoly Kiyatkin is a Research Scientist working in Dr. Lemmon’s lab on the projects that are focused on the analysis of the dynamics of receptor tyrosine kinase-mediated cell signaling networks with a goal to understand design principles of regulatory network structures that play critical roles in cell fate decisions. Email Anatoly at anatoly.kiyatkin[at]yale.edu.

 
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David Lu

David is a Yale College undergraduate studying the effects of lung cancer mutations on EGFR stability and kinase activity. After college, David plans to pursue an MD/PhD. Email David at david.lu[at]yale.edu.

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Krishna Mudumbi, Ph.D.

Krishna is a postdoctoral associate interested in studying the kinetics of receptor tyrosine kinase dimerization and signaling through the use of single-molecule microscopy. Outside of lab, he enjoys playing music and board games. Email Krishna at krishna.mudumbi[at]yale.edu.

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Nithya Krishnamurthy

Nithya is a Yale College undergraduate studying the signaling mechanism of T-cell co-signaling receptors TIM-3,PD1, and CTLA-4. After college, Nithya hopes to become a physician-scientist in the field of oncology Email Nithya at nithya.krishnamurthy[at]yale.edu.

 
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Zaritza Petrova

Zaritza is a graduate student in pharmacology interested in the molecular and biophysical underpinnings of EGF receptor activation and the involvement of the C-tail in the process. She spends her free time drinking cappuccino, running, skiing, and traveling. Her favorite lab equipment is the AKTA Pure. Email Zaritza at zaritza.petrova[yale].edu.

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Pouyan Rahmani

Pouyan is the Institute Coordinator of the lab spaces for the Cancer Biology Institute. He earned his master’s degree in Biomedical Sciences from Quinnipiac University, and before joining YCBI he was at the department of Ophthalmology as a Postgrad Associate. In his free time he enjoys traveling and hiking. Email Pouyan at pouyan.rahmani[at]yale.edu.

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Joshua Sheetz

Josh is a graduate student in pharmacology intrigued by the diversity of signaling mechanisms by the protein kinase fold. His work focuses primarily on the mechanistic basis of signaling by the receptor tyrosine pseudokinases. When he isn't searching the PDB, he may be found searching for new hiking trails or cycling routes. Email Josh at joshua.sheetz[at]yale.edu.

 
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Courtney Smith

Courtney is a graduate student in pharmacology interested in understanding how immune co-inhibitory and co-stimulatory receptors modulate T cell signaling, with a specific focus on the co-inhibitory receptor TIM3. By combining biochemical and biophysical approaches with cellular signaling studies, she is working to understand how TIM3 transmits signals across the membrane, and further, how TIM3 signaling is regulated by its ligands. Email Courtney at courtney.smith[at]yale.edu.

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Anselm Sommer, Ph.D.

Anselm is a postdoctoral fellow interested in protein-lipid interactions and is currently working on deciphering the enigmatic Wnt-Signaling properties. When he can’t be found in the lab, he is either watching soccer (Nur Holstein Kiel!), training in the gym, drinking beer or dancing in Brooklyn. Contact Anselm at anselm.sommer[at]yale.edu.

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Steve Stayrook, Ph.D.

Steve is director of the biophysics core facility at the Cancer Biology Institute. Email Steve at steve.stayrook[at]yale.edu.

 
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Yuko Tsutsui, Ph.D.

Yuko is a research scientist who thinks nothing but science. Her primary interest is finding ways to manipulate signaling cascades by modulating protein dynamics via protein localization control and/or ligand binding. Email Yuko at yuko.tsutsui[at]yale.edu.

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Iris Van Alderwerelt Van Rosenburgh

Iris is a graduate student studying the effects of EGFR kinase domain mutations on signaling and dimerization of the receptor. Outside the lab you'll find her coaching the Yale Graduate Crew to victory. Email Iris at iris.vanalderwereltvanrosenburgh[at]yale.edu.

 

Lab Alumni

Diego Alvarado, Ph.D. / Director of Research, Celldex Therapeutics, New Haven, CT
Stephen Artim, V.M.D., Ph.D. / Research Scientist, MIT, Cambridge, MA
Mark A. Baumeister, Ph.D. / Senior Manager, R&D, OraSure Technologies, Richmond, CA
Mitchell B. Berger, M.D., Ph.D. / Obstetrics/Gynecology specialist (Female Pelvic Medicine and Reconstructive Surgery), Urogynecology Associates of Philadelphia, PA
Nicholas Bessman, Ph.D. / Postdoctoral Researcher, Sonnenberg Lab, Weill Cornell Medical College
Kelley A. Bethoney, Ph.D. / High School Teacher at The Episcopal Academy, Newtown Square, PA
Scott C. Bresler, M.D., Ph.D. / Assistant Professor of Pathology and Dermatology, University of Michigan, Ann Arbor, MI
Sung-Hee H. Choi, Ph.D. / Discovery Scientist/Protein Biochemist, Bayer Crop Science. Boston MA
Jessica P. Dawson, Ph.D. / Associate Director, EMD Serono, Inc., Boston, MA
Daniel M. Freed, Ph.D./ Scientist, Translational Medicine, G1 Therapeutics, Research Triangle Park, NC
Valerie M. Giordano, Ph.D. / Associate Professor of Biology, St. Joseph’s College, New York, NY
Jennifer M. Kavran, Ph.D. / Assistant Professor of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
David Keleti, Ph.D. / Clinical Market Intelligence Research Manager, AmeriHealth Caritas, Bala Cynwyd, PA
Jon A. Kenniston, Ph.D. / Associate Director, Discovery Research, Shire, Cambridge, MA
Megan C. King, Ph.D. / Associate Professor of Cell Biology, Yale University, New Haven, CT
Daryl E. Klein, M.D., Ph.D. / Assistant Professor of Pharmacology, Yale University, New Haven, CT
Anthony Lee, Ph.D. / Programmer, City Morph Studio
Ketan Malhotra, Ph.D. / Postdoctoral Fellow, Cambridge University, Cambridge, UK
Jeannine M. Mendrola, Ph.D. / Manager, Molecular Biology, WuXi App Tec, Philadelphia, PA
Jason O. Moore, Ph.D. / Scientist, Janssen Pharmaceuticals, Malvern, PA
Katarina Moravcevic, Ph.D. / Scientist, Janssen Pharmaceuticals, Malvern, PA
Kartik Narayan, Ph.D. / Deputy Director, Sanofi Pasteur, Swiftwater, PA
Camilla L. Oxley, D. Phil. / Senior Scientist, Janssen Pharmaceuticals, Malvern, PA
Jin H. Park, Ph.D./ Postdoctoral Associate, Weill Cornell Medical College
Mira Sachdeva, M.D., Ph.D., / Assistant Professor of Opthalmology, Johns Hopkins School of Medicine, Baltimore, MD
Vijay G. Sankaran, M.D., Ph.D. / Assistant Professor of Pediatrics, Harvard Medical School, Boston, MA
Fumin Shi, Ph.D. / InnoScouting, MD
Kelsey Speer, Ph.D., / Postdoctoral Fellow, Barott Lab, University of Pennsylvania, Philadelphia, PA
Jong W. Yu, Ph.D. / Manager, GSK, Collegeville, PA
Neo Zhengyi Wu, Ph.D. / Software Engineer | Scientist, Google Inc., Seattle, WA